Polynucleotides—also known as Salmon DNA, Sodium DNA, or PDRN—are naturally derived molecules used to support skin regeneration and repair. These powerful compounds stimulate collagen and elastin production, reduce inflammation, and improve hydration, making them a regenerative option for clients looking to promote long-term skin vitality.
At ReSpa Palm Beach, we use polynucleotide-rich formulations delivered through mesoneedling or targeted injection. This facial treatment is performed by expert providers including Brittany Madison, APRN-C, MSN, and Cintia Hultz, PA-C. Whether you’re addressing dryness, dullness, or early aging, this biocompatible skin booster works with your body to restore a healthier glow.
How Do Polynucleotides Work?
Polynucleotides promote skin renewal by mimicking the body’s natural repair processes. Once infused into the skin, they encourage cellular regeneration and activate fibroblasts (the cells responsible for producing collagen and elastin). This makes them ideal for restoring elasticity, improving tone, and reducing the visible signs of aging.
At ReSpa Palm Beach, we typically use mesoneedling (a shallow microneedling technique) to deliver the Lumicen Ampoule into the skin. The fine microchannels allow for maximum absorption of the polynucleotide serum, while the controlled skin injury boosts collagen on its own. In some cases, a fine-needle injection technique may be used instead, depending on the treatment area and desired outcome.
What Concerns Can Polynucleotides Improve?
Polynucleotide therapy is safe for all skin types and can be used on the face, neck, and hands. It is ideal for treating:
Some clients also benefit from this treatment for stretch marks or hair restoration, depending on formulation.
What Is the Treatment Process Like?
Each treatment begins with a consultation to determine your needs. After a gentle cleanse, your provider will apply a topical numbing cream for comfort. The polynucleotide serum is then infused using either a microneedling device or targeted injections across the treatment area.
Sessions typically last 30 to 60 minutes, and while you may be slightly pink afterward, most clients experience little to no discomfort and can return to daily activities right away.
What Are the Benefits of Polynucleotide Therapy?
This treatment offers a holistic approach to skin rejuvenation, working below the surface to strengthen your skin’s foundation. Benefits include:
Because the treatment uses biocompatible materials derived from salmon DNA, it is well-tolerated and carries a low risk of side effects.
What Should I Expect After Treatment?
Mild redness, pinpoint swelling, or sensitivity may occur at the treatment site, especially after injection-based application. These side effects typically subside within 24 to 48 hours. To support healing and maximize results:
Your provider will give detailed aftercare instructions tailored to your skin.
Can I Combine Polynucleotides with Other Skin Treatments?
Yes. This regenerative therapy works well alongside other collagen-stimulating or tightening treatments. Common pairings include:
Combining treatments can amplify results, especially when addressing more than one skin concern.
Why Choose ReSpa Palm Beach for Polynucleotides?
At ReSpa, we specialize in regenerative aesthetics — enhancing your natural features with techniques and products that honor the integrity and structure of your face. Each treatment plan is thoughtfully customized by our providers according to your goals, timeline, and unique facial anatomy, with a strategic year-long roadmap for optimal results.
We believe consistency is essential to achieving refined, lasting outcomes, and we guide you every step of the way to ensure your results evolve beautifully over time.
Restore Skin from Within with Polynucleotides in Palm Beach
Polynucleotide therapy is a powerful solution for restoring skin health from the inside out. Whether you’re looking to reduce wrinkles, boost hydration, or enhance your skin’s natural resilience, this treatment offers regenerative support without fillers or downtime.
To learn more or schedule your consultation, contact us or call (561) 782-1474.
Questions & Answers
Answers to some of the most frequently asked questions from our clients. Have a question that’s not answered here? Contact ReSpa directly and we will be happy to provide you with answers.
The number of treatments varies depending on your goals and the area being treated. Generally, 3 to 5 sessions spaced 2 to 4 weeks apart are recommended to achieve optimal results. Your ReSpa healthcare provider will assess your needs and recommend a tailored treatment plan.
Polynucleotide injections have minimal downtime. You might experience mild swelling, redness, or bruising at the injection site, which usually subsides within 24 to 48 hours.
Most patients can resume normal activities immediately after the procedure, though it’s advised to avoid strenuous exercise for a day or two.
Our PDRN skin booster is ideal for individuals seeking to improve skin hydration, reduce fine lines, or promote healing in damaged tissues.
It’s also beneficial for those with mild to moderate signs of aging or skin conditions.
Results may start to appear after the first session, but most patients notice significant improvement after 2 to 3 sessions. Full results are typically seen a few weeks after completing the entire treatment series, as the polynucleotides work to stimulate long-term tissue repair and rejuvenation.
To maximize your results, follow your doctor’s aftercare instructions, which may include staying hydrated, applying gentle skincare products, and avoiding sun exposure or harsh treatments for a few days after the procedure. Consistency with the recommended treatment plan will also enhance outcomes.
Wear comfortable, loose-fitting clothing to your appointment, especially if you are getting treated in an area like the legs or arms. This will ensure easy access to the treatment site and help you feel more relaxed during the procedure.
Disclaimer: The material contained on this site is for informational purposes only and DOES NOT CONSTITUTE THE PROVIDING OF MEDICAL ADVICE, and is not intended to be a substitute for independent professional medical judgment, advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare providers with any questions or concerns you may have regarding your health.
